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Filtered Search Results
Medchemexpress LLC Mc-val-ala-oh | 1342211-31-7 | MFCD27956998 | 99.8% | 381.42 g/mol | C18H27N3O6 | 25 MG
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MC-Val-Ala-OH is a cleavable antibody-drug conjugate (ADC) linker that incorporates a valine-alanine dipeptide and a maleimide reactive handle. It acts as a protease-sensitive spacer to enable intracellular release of conjugated payloads and is provided as a high-purity solid for research use only.
- Protease-sensitive val-ala dipeptide for intracellular cleavage
- Maleimide reactive handle for thiol-selective conjugation
- High purity suitable for research-grade ADC synthesis
- Soluble in common organic solvents such as DMSO
- Available in lab-scale quantities for small-batch synthesis
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Medchemexpress LLC H-Val-Pro-Pro-OH (TFA) | 2828433-08-3 | 98.0% | 425.40 | 50 MG
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H-Val-Pro-Pro-OH (TFA) is a milk-derived proline peptide derivative that acts as an inhibitor of Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM. For research use only, not sold to patients. H-Val-Pro-Pro-OH (TFA) can enhance insulin sensitivity and prevent insulin resistance in 3T3-F442A pre-adipocytes. It also possesses anti-hypertensive and anti-inflammatory functions, and can enhance the expression of glucose transporter 4 (GLUT4) in adipocytes and restore glucose uptake in TNF-treated adipocytes.
- Inhibitor of Angiotensin I converting enzyme (ACE)
- Enhances insulin sensitivity
- Prevents insulin resistance in 3T3-F442A pre-adipocytes
- Anti-hypertensive properties
- Anti-inflammatory functions
- Enhances expression of glucose transporter 4 (GLUT4) in adipocytes
- Restores glucose uptake in TNF-treated adipocytes
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Medchemexpress LLC H-Val-Ala-OH (Standard) | 27493-61-4 | 188.23 | 1G
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H-Val-Ala-OH (Valyl-alanine) is a dipeptide formed from L-Valine and L-Alanine residues, functioning as a metabolite with a bitter taste. It is intended for research use only as an analytical standard for qualitative, quantitative, and methodological research experiments.
- Dipeptide derived from L-Valine and L-Alanine
- Acts as a metabolite
- Possesses a bitter taste
- Used as an analytical reference standard
- Applicable in HPLC, GC, and MS research techniques
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eMolecules 159858-22-7 | Fmoc-Val-Cit-PAB-OH | Ambeed | MFCD22417106 | 601.704 | C33H39N5O6 | 98.000 | CC(C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(=O)N[C@@H](CCCNC(N)=O)C(=O)Nc1ccc(CO)cc1 | 100g | 846262358
Fmoc-Val-Cit-PAB-OH | Ambeed | 159858-22-7 | MFCD22417106 | 601.704 | C33H39N5O6 | 98.000 | CC(C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(=O)N[C@@H](CCCNC(N)=O)C(=O)Nc1ccc(CO)cc1 | 100g | 846262358
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eMolecules 159857-81-5 | Mc-Val-Cit-PABC-PNP | ChemScene | MFCD22200431 | 737.767 | C35H43N7O11 | 98.000 | CC(C)[C@H](NC(=O)CCCCCN1C(=O)C=CC1=O)C(=O)N[C@@H](CCCNC(N)=O)C(=O)Nc1ccc(COC(=O)Oc2ccc(cc2)[N+]([O-])=O)cc1 | 250mg | 654744069
Mc-Val-Cit-PABC-PNP | ChemScene | 159857-81-5 | MFCD22200431 | 737.767 | C35H43N7O11 | 98.000 | CC(C)[C@H](NC(=O)CCCCCN1C(=O)C=CC1=O)C(=O)N[C@@H](CCCNC(N)=O)C(=O)Nc1ccc(COC(=O)Oc2ccc(cc2)[N+]([O-])=O)cc1 | 250mg | 654744069
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Medchemexpress LLC Oh-glu-val-cit-pab-mmae | 1895916-23-0 | MFCD34676998 | 99.0% | 1237.53 | C63H100N10O15 | 5 MG
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A cleavable antibody-drug conjugate (ADC) reagent combining an OH-Glu-Val-Cit-PAB cleavable linker with the cytotoxic payload monomethyl auristatin E (MMAE), supplied for research use in ADC synthesis.
- Cleavable linker conjugated to a tubulin inhibitor for ADC construction.
- High purity suitable for research applications.
- Supplied as a 5 mg unit; larger sizes available on request.
- Store sealed at -20°C, protected from moisture and light; in solvent store at -80°C for up to 6 months.
- Includes CAS 1895916-23-0 and molecular weight 1237.53 for reference.
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Medchemexpress LLC DL-Valine | 516-06-3 | 98.0% | 117.15 | 100 G
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DL-Valine is a valine derivative. Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances.
- Valine derivative
- Used as an ergogenic supplement
- Influences the secretion of anabolic hormones
- Supplies fuel during exercise
- Enhances mental performance during stress-related tasks
- Prevents exercise-induced muscle damage
- Recognized as a beneficial ergogenic dietary substance
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Medchemexpress LLC Py-maa-val-cit-pab-mmae | 2247398-68-9 | 98.5% | 1446.79 | C72H111N13O16S | 50 MG
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Py-MAA-Val-Cit-PAB-MMAE is a drug-linker conjugate used as a building block in antibody-drug conjugate (ADC) synthesis. It links the cytotoxic payload MMAE to a protease-cleavable Val-Cit-PAB linker via a Py-MAA spacer and is intended for research use in ADC development.
- Protease-cleavable Val-Cit-PAB linker for controlled payload release
- Contains a Py-MAA spacer for conjugation flexibility
- Includes monomethyl auristatin E (MMAE) as the cytotoxic payload
- Supplied as a dry material suitable for organic solvent handling
- Intended for research and development applications in ADC synthesis
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STA Pharmaceutical Fmoc-L-beta-HomoVal-OH | 25 g | CAS 172695-33-9 | MDL MFCD01862853
Fmoc-L-beta-HomoVal-OH is a Amino Acid reagent (Subcategory: Beta AA) sold by WuXi TIDES. Offered in 25 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 172695-33-9
- MDL: MFCD01862853
- InChIKey: KFDMTAMWOIQTOB-LJQANCHMSA-N
- Molecular Weight: 353.418
- Molecular Formula: C21H23NO4
- Purity: ≥95%
- Container Type: 125 mL HDPE
- Pack Size: 25 g
- Net Weight: 25 g
- Gross Weight: 54.3 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: (R)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-methylpentanoic acid
- SMILES: CC(C)[C@@H](CC(O)=O)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O
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Medchemexpress LLC Fmoc-VAP-MMAE | 1912408-91-3 | 1259.57 | 10 MG
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Fmoc-VAP-MMAE is an agent-linker conjugate for Antibody-Drug Conjugates (ADC). It consists of an ADC linker, a tubulin inhibitor MMAE (HY-15162), and a protective Fmoc group. It is intended for research use only and is not sold to patients. The appearance is a solid, white to off-white in color.
- Agent-linker conjugate for ADC
- Composed of an ADC linker and MMAE, a tubulin inhibitor
- Features a protective Fmoc group
- Intended for research use only
- Appearance: solid, white to off-white in color
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Dianhydrodulcitol; Dianhydrogalactitol | 23261-20-3 | 98.0% | 146.14 | 1 ML
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VAL-083 is an alkylating agent designed for research use, primarily known for creating N7 methylation on DNA and exhibiting antitumor activity. It suppresses cancer cell growth, induces apoptosis, and inhibits the proliferation of various cancer cell lines in a dose-dependent manner.
- Alkylating agent that creates N7 methylation on DNA.
- Suppresses U251 and SF188 cell growth and induces apoptosis.
- Inhibits the proliferation of various cancer cell lines in a dose-dependent manner.
- Suppresses migration and invasion by reducing MMP2, VEGF, VEGFR2, and FGF2 expression.
- Induces cell cycle arrest at G2/M phase in glioma cell lines.
- Enhances radiosensitivity and inhibits angiogenesis.
- Blocks growth of LN229 cells in mice, with an 83.58% tumor growth inhibitory rate.
- Potential multitarget agent for glioblastoma; new treatment option.
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Medchemexpress LLC D-Isovaline | 3059-97-0 | 97.0% | 117.15 | 1 G
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D-Isovaline is a valine derivative, recognized as a beneficial ergogenic dietary substance. It is commonly used as an ergogenic supplement, influencing the secretion of anabolic hormones and the supply of fuel during exercise.
- Supports mental performance during stress-related tasks
- Helps prevent exercise-induced muscle damage
- Influences anabolic hormone secretion
- Supplies fuel during exercise
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Aminocaproyl-val-cit-PABC-MMAE | 1374407-35-8 | 99.9% | 1236.58 | 50 MG
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Aminocaproyl-Val-Cit-PABC-MMAE is a drug-linker conjugate for antibody-drug conjugates (ADC). It is utilized in cancer research and targeted therapy contexts.
- Drug-linker conjugate for ADC
- Used in cancer research
- Suitable for cancer targeted therapy
- Functions as an inhibitor
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Medchemexpress LLC Azido-PEG(4)-Val-Cit-PAB-PNP | 1869126-60-2 | C36H51N9O13 | 50 MG
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Azido-PEG(4)-Val-Cit-PAB-PNP is a cleavable peptide ADC linker. It functions as a click chemistry reagent, featuring an azide group. This reagent is designed to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups, and can also participate in ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules possessing DBCO or BCN groups.
- Cleavable peptide ADC linker
- Functions as a click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups
- Can participate in ring strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC mp-dLAE-PABC-MMAE | 2625616-44-4 | 98.3% | 1331.59 g·mol⁻1 | C68H102N10O17 | 10 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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mp-dLAE-PABC-MMAE is a drug-linker conjugate designed for use in antibody-drug conjugate (ADC) synthesis. The compound incorporates monomethyl auristatin E as the cytotoxic payload and a para-aminobenzyl carbamate (PABC) cleavable spacer, and is supplied in milligram quantities for research and development.
- Contains monomethyl auristatin E, a potent tubulin inhibitor.
- Includes a PABC cleavable linker for enzyme-triggered payload release.
- Supplied as a solid in multiple milligram sizes suitable for ADC conjugation workflows.
- Molecular formula C68H102N10O17 and high purity for research applications.
- Suitable for preclinical ADC synthesis and payload conjugation studies.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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